Chapter 1: The Role of the Advanced Practice Nurse as Prescriber

• Roles and responsibilities of APRN prescribers
• Clinical judgement in Prescribing

Chapter 2: Review of Basic Principles of Pharmacology

• Metabolism: Metabolism & Half Life
• Drug Responses
• Receptors: agonists, antagonists
• Pharmacokinetics: Absorption, Distribution, Protein Binding, Metabolism (including first-pass and Phase I and II)
• Cytochrome P450 metabolism
• Excretion: Renal, Biliary, Other (eg for volatile drugs)

Chapter 3: Rational Drug Selection

• Process of rational drug prescribing: 6 Steps proposed by WHO
• Patient education
• Monitor effectiveness
• Drug, Patient, and Provider factors that influence drug selection
• Influences on Rational Prescribing: Pharmaceutical Promotion

Chapter 4: Legal and Professional Issues in Prescribing

• New Drug Approval process including Clinical Phases.
• U.S. FDA Regulatory Jurisdiction:  official labelling vs off-label use of drugs

Chapter 5: Adverse Drug Reactions

• Mechanistic Classification of ADRs including Types of Immune-Mediated ADRs and Types A-F
• Common Causes of ADRs: Risk Factors, including common drugs involved and which cause skin reactions
• Time-Related Classification of ADRs including drugs associated with withdrawal symptoms
• Dose-Related ADRs classification.

Chapter 6: Factors that Foster Positive Outcomes

• Overview of nonadherence
• Keys to effective patient education
• Health and Cultural beliefs
• Health Literacy
• Complexity of Drug Regimen and Polypharmacy
• Simplifying the Regimen
• Communication Difficulties

Chapter 9: Nutrition and Nutraceuticals

• Nutrient-Drug Interactions (eg warfarin and vit K)
• Influence of Diet on Pharmacokinetics of Drugs:
• infants and children
• women of child bearing age
• pregnant women
• vegans
• older adults
• those not exposed to sunlight or with dark skin
• alcoholics
• patients taking isoniazid (INH)
• Nutraceuticals:
• Vitamin that is teratogenic in excessive amounts
• Vitamin that is useful for migraine prophylaxis

Chapter 12: Pharmacoeconomics

• Know what Pharmacoeconomics is
• Impact of Cost: Direct and Indirect

Chapter 13: Over-the-counter Medications

• OTC Medication characteristics and regulation
• OTC Medication Sales
• Hazards of OTC Self-Medication
• Adverse Effects of OTC Self-Medication
• Drug Interactions: antacids, anticholinergics, CNS Depressants, NSAIDS and ASA
• Abuse of OTC Medications: Combat Methamphetamine Epidemic Act
• Patient Education Regarding OTC Medications

Chapter 14 Drugs Affecting the Autonomic Nervous System

• Pharmacodynamics of Alpha2 Agonists
• Pharmacodynamics of Beta Blockers, adverse effects, what happens with abrupt withdrawal of Beta Blockers?
• Pharmacokinetics: Beta blockers
• Phamacotherapeutics: precautions and Contraindications of beta blockers
• Adverse Drug Reactions
• Clinical Uses and Dosing of Beta Blockers pg 194-195 see the table to review!
• Muscarinic Agonists: Pharmacodynamics, MOA, treatment uses,

Chapter 15 Drugs Affecting the Central Nervous System

• Anorexiiants
• Iminostilbenes
• Succinimides:.
• Drugs That Affect GABA
• Tricyclic Antidepressants (TCA
• Monoamine Oxidase Inhibitors(MAOIs):
• SSRI

Chapter 28 Chronic Stable Angina and Low Risk Unstable Angina

Additional Patient Variables: Concomitant Diseases

• MI
• HF
• HTN
• Hypercholesterolemia
• Peripheral vascular disease
• Diabetes Mellitus
• Asthma
• Erectile Dysfunction

Beta Blocker-diabetes Mellitus

Chapter 36: Heart Failure

• Indications for heart failure drugs by stage
• First line drugs of choice for heart failure
• MOA of ACEIs that benefit heart failure
• Indications for use of BBs in patients with heart failure
• Drugs that increase life expectancy in patients with heart failure
• Digoxin indications and adverse reactions
• Drugs contraindicated in heart failure
• Drugs for managing heart failure during pregnancy
• Patient monitoring of HF
• Indications to use anticoagulant therapy
• Patient education

Chapter 40 Hypertension

• Classes of drugs used and their MOAs: Nitrates, BBs, CCBs, ACEIs
• What drugs increase myocardial oxygen supply
• Causes of hypertension
• Which drugs treat hypertension & BPH, MI, Heart Failure African Americans.

Chapter 14: Drugs Affecting the Autonomic Nervous System

• Adrenergic Agonists
• Alpha2 Agonists: Central 
• Alpha1 Antagonists 
• Combined Alpha- and Beta-Adrenergic Antagonists 
• Name of drugs in this category
• Indications for use
• Pharmacodynamics
• Precautions
• ADRs
• Drug interactions of carvedilol
• clinical use: HTN, CHF (what stage of CHF is an indication to use?);
• Withdrawal of alpha-beta blockers
• concomitant diseases
• Monitoring
• Cholinergic Agonists

Chapter 15: Drugs Affecting the Central Nervous System

• Anorexiants 
• Anticonvulsants 
• Benzodiazepines
• Uses including status epilepticus

Chapter 29: Anxiety and Depression

• Classes of Medications
• ADRs
• Special Populations
• Outcome Evaluation
• Clinical Pearls

Chapter 43: Smoking Cessation

• Rational Drug Selection
• Tobacco-cessation therapies