NR 507 Week 4 Midterm Review
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| Institution | NR 507 Advanced Pathophysiology |
| Contributor | Mireille |
NR 507: MIDTERM REVIEW
Hematology
Hematopoiesis: -process of blood cell production
-Constant throughout life to replace RBCs that grow old and die, are killed by disease, or are lost through bleeding
-Occurs in liver and spleen of fetus
-Occurs in bone marrow after birth
-2 stages: 1. Proliferation (mitotic division)
- Maturation (differentiation)
-Bone marrow: red (hematopoietic/active) & yellow (fatty/inactive)
Hematopoietic stem cells (HSCs)- all blood cells are created from HSCs
-signaled to undergo differentiation (by cytokines and chemokines, growth factors) to form RBC, WBC, & platelets
- Lymphoid: T cell (T-lymphocyte) & B cell (B-lymphocyte)
- Myeloid: Monocyte & Granulocytes (WBCs)
- Erythrocyte (RBC)
- Megakaryocyte (Platelets)
Mesenchymal stem cells-develop into osteoclasts, fibroblasts, & adipocytes
Erythropoietin: -hormone that stimulates erythrocyte production
-Secreted by the kidneys in response to tissue hypoxia
Erythrocyte: -most abundant cells in the body
-primarily responsible for tissue oxygenation
-mature erythrocytes lack a nucleus and mitochondria, cannot synthesize protein or carry out oxidative reactions. Cannot divide *anaerobic metabolism only
-life span: 100-120 days
-contains hemoglobin molecules
- Stages: (7-day process)
- Hemocytoblast (stem cell) binds with erythropoietin
- Proerythroblast- committed to morph into RBC
- Erythroblast- ribosome synthesis (2 phases)
- Normoblast- Hgb accumulation & nucleus ejection
Reticulocyte –(immature RBC) released into circulation, no nucleus, ribosome, or mitochondria
- RBC (after it has been in bone marrow 1-2 days).......... Continue
| Instituition / Term | |
| Term | Year 2022 |
| Institution | NR 507 Advanced Pathophysiology |
| Contributor | Mireille |
