NR 507 Week 2 Notes
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| Institution | NR 507 Advanced Pathophysiology |
| Contributor | Mireille |
Week 2 Respiratory disorders and alterations in acid-base fluid balance and electrolytes:
Water balance:
Solvent= water
Solute= any substance in water Solution/fluid= water and the substance in it
Movement of water à refers to only water without solute
Basics of Fluid, electrolyte, acid and base balance:
All living organisms are composed of water and the solutes dissolved in it
- Solutes include: electrolytes (Na+, Cl-, K+, Ca+2) and non- electrolytes (proteins and glucose) Why are all living organism water based?
The functions of water include:
- Body temp regulation
- Lubrication (synovium, pleura, pericardium)
- Transportation of nutrients and wastes in and out of cells
- Cellular metabolism medium
Total body water (TBW)à sum of fluids in all compartments
- Approx. 60% of body wt in adults
What are the “compartments”?
- Intracellular fluid (ICF)- fluid within cells à primarily potassium and phosphate
- 40% of body wt
- Extra cellular fluid (ECF)- fluid outside of cells à primarily sodium and chloride
- 20% of body wt
- ECF can be in 3 separate locations:
- Intravascular fluid (IV) – blood plasma 5%
- Interstitial fluid (IF)- fluid between cells and outside of blood vessels 15%
- Other fluids (3rd space)
- lymph, synovial fluid, CSF, intestinal, urine, sweat, intraocular, and body cavity fluids
Both ECF and ICF contain solutes
Solute levels differ between the ECF and ICF but each compartment has the same electroneutrality within given body compartment
Body fluids are in constant movement with 2 way traffic patterns
- Between the ICF and ECF
- Between the plasma (IV) and IF............. Continue
| Instituition / Term | |
| Term | Year 2022 |
| Institution | NR 507 Advanced Pathophysiology |
| Contributor | Mireille |
